New paper in Small
Post date: Aug 3, 2018 12:00:09 AM
Dong Jae Kim, Sung-Gyu Park, Dong-Ho Kim, and Shin-Hyun Kim, "SERS-Active Charged Microgels for Size- and Charge-Selective Molecular Analysis of Complex Biological Samples", Small, accepted for publication (2018). (Co-corresponding author)
SERS-active charged microgels are microfluidically designed by embedding agglomerates of gold nanoparticles in a matrix. The microgels concentrate oppositely-charged small molecules while excluding large proteins. As nanogaps among gold nanoparticles serve as hot spots for SERS, Raman signal of charged molecules is dramatically enhanced without interruption of protein. Therefore, the microgels enable direct molecular analysis of complex biological samples.