New Communication in Angewandte Chemie

Post date: Apr 20, 2012 1:25:45 PM

Chiara Martino, Shin-Hyun Kim, Louise Horsfall, Alireza Abbaspourrad, Susan Rosser, Jonathan Cooper and David Weitz, "Protein Expression, Aggregation and Triggered Release from a Polymersomes, as Artifical Cell-like Structures," Angewandte Chemie International Edition, Accepted for publication (2012). (Equal contribution)

Structural proteins are expressed in artificial cells comprised of biocompatible polymersomes which encapsulate expression machinery and amino acid building blocks. These polymersomes provide highly stable encapsulation of the materials during the expression and facilitate triggered release of the expressed proteins by a negative osmotic shock; this is difficult to achieve using approaches based on liposomes or emulsions.